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AGC Inhibitor Set , 5x 50 µl
[PKI-AGCSET-250]
Set contains inhibitors which are specific for the AGC family (H8, H89, HA-1004, HA-1077) and staurosporine as a general protein kinase inhibitor. The products are predissolved in DMSO at a stock concentration of 10 mM in 50 µl.
Ordering information: shipped on dry ice
Product specific literature references:
Hidaka H, Inagaki M, Kawamoto S, Sasaki Y. (1984) "Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C." Biochemistry. 23(21):5036-41.
Hagiwara M, Inagaki M, Hidaka H. (1987) "Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase." Mol Pharmacol. 31(5):523-8
Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inoue T, Naito K, Toshioka T, Hidaka H. (1990)"Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(pbromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma". J. Biol. Chem. 265, 5267
Engh RA, Girod A, Kinzel V, Huber R, Bossemeyer D. (1996)"Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity" J. Biol. Chem. 271, 26157
Tamaoki T, Nomoto H, Takahashi I, Kato Y, Morimoto M, Tomita F (1986) "Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase" Biochem. Biophys. Res. Commun. 135(2):397-402
Gescher A. (1998) "Analogs of staurosporine: potential anticancer drugs?" Gen Pharmacol. 31(5):721-8
Crowley MR, Fineman JR, Soifer SJ. (1994) "HA1004, an intracellular calcium antagonist, selectively attenuates pulmonary hypertension in newborn lambs" J. Cardiovasc. Pharmacol. 23, 806
Seto M, Sasaki Y, Hidaka H, Sasaki Y. (1991) "Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle." Eur J Pharmacol. 195(2):267-72.
Takizawa S, Hori M, Ozaki H, Karaki H. (1993) "Effects of isoquinoline derivatives, HA1077 and H-7, on cytosolic Ca2+ level and contraction in vascular smooth muscle." Eur J Pharmacol. 250(3):431-7.
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