5-Iodotubercidin, 5x5 µmol
[PKI-ITUB-025]
5-Iodotubercidin is a potent and specific inhibitor of ERK2 (Ki ~0.5 uM) and adenosine kinase (Ki ~30 nM). It has also been reported to abolish the accumulation of AICAR-5'-monophosphate (ZMP) and thus inhibits the activation of AMPK. Molecular weight 392.2 g/mol. Appearance: light brown solid. Purity: >98% (HPLC). Solubility: soluble in DMSO. Handling: Protect from light. Formula C11H13IN4O4.
Product specific literature references:
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Abbud W, Habinowski S, Zhang JZ, Kendrew J, Elkairi FS, Kemp BE, Witters LA, Ismail-Beigi F (2000) "Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport Arch. Biochem. Biophys. 380(2):347-52
Fleming I, Schulz C, Fichtlscherer B, Kemp BE, Fisslthaler B, Busse R (2003) "AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets" Thromb Haemost. 90(5):863-71
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