8-CPT-cAMP is a lipophilic activator of both cAMP- and cGMP- dependent protein kinase. It has a higher activation potential compared to cAMP and excellent cell membrane permeability, improved phosphodiesterase stability and high site selectivity preferring site B of cAMP-dependent protein kinase type II.  This analogue is not selective but activates cGMP-dependent protein kinase as well. In addition, it increases basal cGMP level by inhibition of PDE V. Molecular weight 470.8 . 23.0 g/mol. Appearance: White lyophilized powder. Purity: ~98%. Formula C₁₆H₁₄ClN₅O₆PS . Na

Product specific literature references:

Peters DJ, Bominaar AA, Snaar-Jagalska BE, Brandt R, Van Haastert PJ, Ceccarelli A, Williams JG, Schaap P (1991) "Selective induction of gene expression and second-messenger accumulation in Dictyostelium discoideum by the partial chemotactic antagonist 8-p-chlorophenylthioadenosine 3',5'-cyclic monophosphate" Proc. Natl. Acad. Sci. U S A. 88(20):9219-23.

Sandnes D, Jacobsen FW, Refsnes M, Christoffersen T (1996) "8-bromo-cAMP and 8-CPT-cAMP increase the density of beta-adrenoceptors in hepatocytes by a mechanism not mimicking the effect of cAMP" Pharmacol. Toxicol. 79(1):15-22

Parvathenani LK, Buescher ES, Chacon-Cruz E, Beebe SJ (1998) "Type I cAMP-dependent protein kinase delays apoptosis in human neutrophils at a site upstream of caspase-3" J. Biol. Chem. 273(12):6736-43

Price*: EUR 68,00

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This product was added to our catalog on Dec 13, 2006


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