Forskolin, 10 mg
[PKE-FORS-010]
Forskolin, is a cell permeable diterpenoid isolated from Coleus forskohlii. Forskolin has a unique ability to stimulate adenylate cyclase activity and increase intracellular cyclic adenosine monophosphate (cAMP) thus activating cAMP-dependent protein kinase and other cAMP receptor proteins. Molecular weight 410.5 g/mol. Solubility: Soluble in anhydrous DMSO, acid ethyl ester or 100% ethanol. Purity: >98% (HPLC). Formula C22H34O7.
Synonyms: colforsin
PLEASE NOTE: Our highly pure research chemicals are provided only to academic and business customers for research use. This product has not been approved for any other purposes including, without limitation, diagnostic or therapeutic purposes, for use in preparation of food or pharmaceutical products nor for administration to humans. We do not supply private customers or non-research organizations with this product.
Product specific literature references:
Seamon KB, Daly JW (1981) "Forskolin: a unique diterpene activator of cyclic AMP-generating systems" J. Cyclic Nucleotide Res. 7(4):201-24.
Fradkin JE, Cook GH, Kilhoffer MC, Wolff J (1982) "Forskolin stimulation of thyroid adenylate cyclase and cyclic 3',5'-adenosine monophosphate accumulation" Endocrinology 111(3):849-56
Barber R, Goka TJ (1985) "Adenylate cyclase activity as a function of forskolin concentration" J. Cyclic Nucleotide Protein Phosphor. Res. 10(1):23-9
Laurenza A, Sutkowski EM, Seamon KB (1989) "Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?" Trends Pharmacol. Sci. 10(11):442-7.
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