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Recombinant human BAFFR / TNFRSF13C Protein, Fc Tag, 100 µg  

Recombinant human BAFFR / TNFRSF13C Protein, Fc Tag, 100 µg

Recombinant human BAFFR / TNFRSF13C, Ser 7 - Ala 71, expressed from human 293 cells (HEK293), Fc Tag

Synonym
recombinant, human, protein, BAFFR, TNFRSF13C, BAFF-R, BROMIX, CD268, CVID4, prolixin

More details

BAR-H5257-100

455,00 €

Background
BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

Source
Recombinant human BAFFR / TNFRSF13C, Fc Tag (BAR-H5257) is expressed from human 293 cells (HEK293). It contains AA Ser 7 - Ala 71 (Accession # Q96RJ3-1).
Predicted N-terminus: Ser 7

Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 33.2 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin
Less than 1.0 EU per μg by the LAL method.
 
Purity
>95% as determined by SDS-PAGE.

Formulation
Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
 
Bioactivity
Please refer to product data sheet.

Clinical and Translational Updates

(1) "Autoimmune Neutropenias: Update on Clinical and Biological Features in Children and Adults"
Fioredda, Dufour, Höglund et al
Hemasphere (2023) 7 (1), e814
(2) "CAR-T cell Therapies for B-cell Lymphoid Malignancies: Identifying Targets Beyond CD19"
Vanegas, Mohty, Gadd et al
Hematol Oncol Stem Cell Ther (2022) 15 (3), 81-93
(3) "Neutrophilic granulocyte-derived B-cell activating factor supports B cells in skin lesions in hidradenitis suppurativa"
Sabat, Šimaitė, Gudjonsson et al
J Allergy Clin Immunol (2022)
Showing 1-3 of 536 papers.