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Recombinant Human ACE2 / ACEH Protein, His Tag, 1mg  

Recombinant Human ACE2 / ACEH Protein, His Tag, 1mg

Recombinant human ACE2 / ACEH Protein, AA Gln 18 - Ser 740, expressed from human 293 cells (HEK293), His Tag

Synonyms: Recombinant, protein, ACE-2, ACEH, ACE2

More details

AC2-H52H8-1K

Availability: within 10-14 days

2 800,00 €

Background
Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.

Source
Recombinant Human ACE2, His Tag (AC2-H52H8) is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Ser 740 (Accession # Q9BYF1-1).Predicted N-terminus: Gln 18

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 86.2 kDa.

Formulation
This product is supplied as sterile liquid solution.

Bioactivity
Please refer to product data sheet.

Storage
The product MUST be stored at -70°C or lower upon receipt, -70°C for 3 months under sterile conditions.

References

(1) Turner AJ., et al., 2002, Can. J. Physiol. Pharmacol. 80 (4): 346–53.
(2) Katovich MJ., et al., 2005, Exp. Physiol. 90 (3): 299–305.
(3) Donoghue M., et al., 2000, Circ. Res. 87:E1-E9.
(4) Tipnis S.R., et al., 2000, J. Biol. Chem. 275:33238-33243.
(5) Vickers C., et al., 2002, J. Biol. Chem. 277:14838-14843.

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