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GMP Human IL-15 Protein, 50µg  

GMP Human IL-15 Protein, 50µg

GMP Human IL-15 Protein, AA Asn 49 - Ser 162, expressed from E.coli, (Bioactivity and Stability tested)

Designed under ISO 9001:2015 and ISO 13485:2016,Manufactured and QC tested under a GMP compliance factory, FDA DMF filed

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Availability: within 7 days

540,00 €

Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.

- Designed under ISO 9001:2015 and ISO 13485:2016
- Manufactured and QC tested under a GMP compliance factory
- FDA DMF filed
- Animal-Free materials
- Batch-to-batch consistency
- Stringent quality control tests
- No animal derived peptone and lactose used in production process

GMP Human IL-15 Protein(GMP-L15H13) is expressed from E. coli cells. It contains AA Asn 49 - Ser 162 (Accession # P40933-1 ). Predicted N-terminus: Met

Molecular Characterization
This protein carries no "tag". The protein has a calculated MW of 12.8 kDa. The protein migrates as 13 kDa±3 kDa under reducing (R) condition (SDS-PAGE).

Less than 10 EU per mg by the LAL method.

Host Cell Protein
<0.5 ng/µg of protein tested by ELISA.

Host Cell DNA
<0.02 ng/μg of protein tested by DNA Fluorescent Staining method.

The sterility testing was performed by membrane filtration method described in CP<1101>, USP<71> and Eur. Ph. 2.6.1.


In vitro virus assay

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in 25 mM His, pH6.2 with protectants.

Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping at ambient temperature. Upon receipt, store it immediately at -20°C or lower for long term storage.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 5 years in lyophilized state;
Please refer to product data sheet.

Clinical and Translational Updates

(1) Nguyen, Shetty et al. (2024),"Gulf War illness with or without post-traumatic stress disorder: differential symptoms and immune responses" Mil Med Res 11 (1), 5
(2) Yu, Li, Lu et al (2024), "Fc receptor-like 5 (FCRL5)-directed CAR-T cells exhibit antitumor activity against multiple myeloma"
Signal Transduct Target Ther 9 (1), 16
(3) Miller, Rhein, Davis et al (2024)"Safety and virologic impact of haploidentical NK cells plus IL-2 or N-803 in HIV infection"
J Infect Dis

Showing 1-3 of 3 papers.