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Tyrosine kinases can be classified as receptor protein kinases...
Spleen tyrosine kinase (Syk) along with Zap-70, belong to the Syk family of tyrosine kinases and share a characteristic dual SH2 domain separated by a linker domain. Both kinases are primarily expressed in hematopoietic tissues and abnormal function has been implicated in several malignancies. Proteinkinase.de offers specific small molecule inhibitors targeting Syk family kinases for scientific research.
Epidermal growth factor receptor (EGFR) family are transmembrane receptor tyrosine kinases playing an important roles in cell proliferation and are frequently overexpressed in a variety of carcinomas. The category comprises small molecule inhibitors targeting the catalytic activity of EGFR family members and offered for biochemical research.
Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors subdivided into PDGFR alpha and PDGFR beta. PDGFR signaling contributes to multiple tumor associated processes. PDGFR Inhibitors offered by Proteinkinase.de are selective and specific small molecules targeting PDGFR kinase activity.
Vascular endothelial growth-factor receptors (VEGFRs) Vascular endothelial growth factor receptors play essential roles in the regulation of angiogenesis and lymphangiogenesis. VEGF is often found overexpressed in tumors, as well as its receptors VEGFR1 and VEGFR2. VEGFR inhibitors offered by Proteinkinase.de are specific targeted agents that can be used for protein kinase research.
Src family of protein tyrosine kinases (SFKs) are nonreceptor tyrosine kinases that plays key roles in regulating signal transduction. Src family kinase activation and protein levels are elevated in various types of cancers and the regulation of Src kinase activity has been intensively studied. Proteinkinase.de provided several potent small molecule inhibitors selective for SFKs.
5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-pyperidinyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-Pyrimidinediamine NVP-TAE684 is a potent, selective and efficacious inhibitor of NPM-ALK, protein kinase inhibitor
4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino] benzamide Nilotinib is a highly selective inhibitor of Bcr-Abl, AMN 107, Tasigna, protein kinase inhibitor
4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-[3-(4-methyl-piperazin-1-yl)propoxy]quinoline-3-carbonitrile SKI606 is a Src family tyrosine kinase inhibitor (TKI), targeting dual Bcr-Abl and Src,protein kinase inhibitor
4-Amino-N-(2,5-dihydroxybenzyl)adamantyl Benzoate, 4-(2,5-Dihydroxy-benzylamino)benzoic Acid Adamantan-1-yl Ester, BCR-ABL tyrosine kinase inhibitor, Adaphostin Synonyms: NSC 680410, NSC-680410, BCR-ABL tyrosine kinase inhibitor, Adaphostin
(3R,4R)-3-(2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-6-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione Synonyms: TivantinibARQ 197 is a selective, non-ATP competitive inhibitor of c-MET receptor tyrosine kinase
2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol methanesulfonate PF 04217903 mesylate is an orally bioavailabe tyrosine kinase inhibitor, targeting MET (or c-MET)
N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide Synonyms: OsimertinibAZD 9291 is a potent oral, irreversible, and mutant-selective EGFR inhibitor.
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl] quinazolin-4-amine ditosylate Synonyms: GW-572016Lapatinib ditosylate is an ATP-competitive EGFR and HER2/neu (ErbB-2) dual tyrosine kinase inhibitor.
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