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TK group inhibitors

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Inhibitors for protein tyrosine kinases

Tyrosine kinases can be classified as receptor protein kinases...

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Subcategories

  • Syk / ZAP70 inhibitors

    Selective Syk family inhibitors

    Spleen tyrosine kinase (Syk) along with Zap-70, belong to the Syk family of tyrosine kinases and share a characteristic dual SH2 domain separated by a linker domain. Both kinases are primarily expressed in hematopoietic tissues and abnormal function has been implicated in several malignancies. Proteinkinase.de offers specific small molecule inhibitors targeting Syk family kinases for scientific research.

  • EGFR inhibitors

    Selective EGFR family inhibitors

    Epidermal growth factor receptor (EGFR) family are transmembrane receptor tyrosine kinases playing an important roles in cell proliferation and are frequently overexpressed in a variety of carcinomas. The category comprises small molecule inhibitors targeting the catalytic activity of EGFR family members and offered for biochemical research.

  • PDGFR inhibitors

    Selective PDGFR inhibitors

    Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors subdivided into PDGFR alpha and PDGFR beta. PDGFR signaling contributes to multiple tumor associated processes.  PDGFR Inhibitors offered by Proteinkinase.de are selective and specific small molecules targeting PDGFR kinase activity.

  • VEGFR inhibitors

    Selective VEGFR inhibitors

    Vascular endothelial growth-factor receptors (VEGFRs) Vascular endothelial growth factor receptors play essential roles in the regulation of angiogenesis and lymphangiogenesis. VEGF is often found overexpressed in tumors, as well as its receptors VEGFR1 and VEGFR2. VEGFR inhibitors offered by Proteinkinase.de are specific targeted agents that can be used for protein kinase research.

  • Src kinases inhibitors

    Selective Src Family Kinase Inhibitors

    Src family of protein tyrosine kinases (SFKs) are nonreceptor tyrosine kinases that plays key roles in regulating signal transduction. Src family kinase activation and protein levels are elevated in various types of cancers and the regulation of Src kinase activity has been intensively studied. Proteinkinase.de provided several potent small molecule inhibitors selective for SFKs.


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