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Recombinant human ALK-3/BMPR1A Protein, 200µg  

Recombinant human ALK-3/BMPR1A Protein, 200µg

Recombinant Human ALK-3 /BMPR1A Protein (rhALK3), Gln24-Arg152 was expressed in human 293 cells (HEK293).

Synonym: recombinant, human, protein BMPR-1A, ALK-3, BMPR1A, ALK3, CD292, bone morphogenetic protein receptor type IA

More details

AL3-H5228-200

Availability: within 7 days

312,00 €

Background
The bone morphogenetic protein receptor, type IA also known as BMPR1A or ALK3 is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 290). The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2.[1] Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis.[2]

Source
Recombinant Human ALK-3 /BMPR1A Protein (rhALK3), Gln24-Arg152 (Accession # CAA80257) was expressed in human 293 cells (HEK293)

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.7 kDa. The protein migrates as 23-34 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin
Less than 1.0 EU per μg by the LAL method.

Purity
>95% as determined by SDS-PAGE.

Formulation
Refer to data sheet

Reconstitution
See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage
Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at:
In lyophilized state for 1 year (4C-8C); After reconstitution under sterile conditions for 1 month (4C-8C) or 3 months (-20C to -70C).

Bioactivity
N/A

 

References

(1) Mishina Y, Starbuck MW , et al.(2004). J. Biol. Chem. 279 (26): 27560–6
(2) Song L, Fässler R, et al. (2007). Dev Biol. 301(1):276-86