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Recombinant Mouse EGFR /ErbB1 Protein,  His Tag,1mg  

Recombinant Mouse EGFR /ErbB1 Protein, His Tag,1mg

Recombinant Mouse EGF R Protein (Mouse EGF R, His Tag) Leu 25 - Ser 647 was produced in human 293 cells (HEK293)

Synonym
recombinant, mouse, protein, EGFR, ERBB, ERBB1, HER1, PIG61, mENA

More details

EGR-M5224-1K

Availability: within 7 days

1 980,00 €

Background
The epidermal growth factor receptor (EGFR; ErbB-1; HER1) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands.[1] The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.[2]

Source
Recombinant Mouse EGF R, His Tag (EGR-M5224) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Ser 647 (Accession # Q01279-1).
Predicted N-terminus: Leu 25
Request for sequence

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 71.2 kDa. The protein migrates as 86-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin
Less than 1.0 EU per 1 μg of the mouse EGFRG by the LAL method.

Purity
>95% as determined by SDS-PAGE. All lots are greater than 95% pure.

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

Reconstitution
See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Bioactivity
Please refer to product data sheet.

Clinical and Translational Updates

(1) A standardized g-force allows the preparation of similar PRF qualities regardless of rotor angle"
Al-Maawi, Dohle, Kretschmer et al
Tissue Eng Part A (2021)
(2) Drug combination screening as a translational approach toward an improved drug therapy for chordoma"
Scheipl, Barnard, Lohberger et al
Cell Oncol (Dordr) (2021)
(3) "Identification of a PCSK9-LDLR disruptor peptide with in vivo function"
Brousseau, Clairmont, Spraggon et al
Cell Chem Biol (2021)
Showing 1-3 of 2968 papers.
Please refer to product data sheet.

 

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