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Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.
Recombinant Human ROR1 /NTRKR1 Protein (rh ROR1) Gln 30 - Glu 403 (Accession # Q01973) was produced in human 293 cells (HEK293) at ACROBiosystems.
rh ROR1 is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 43.5 kDa. The predicted N-terminus is Gln 30. DTT-reduced Protein migrates as 55-66 kDa in SDS-PAGE due to glycosylation.
Less than 1.0 EU per μg of the rh ROR1 by the LAL method.
>95% as determined by SDS-PAGE.
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
See Certificate of Analysis for reconstitution instructions and specific concentrations.
Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).
(1) Masiakowski P., et al., 1992, J. Biol. Chem. 267:26181-26190.
(2) Reddy U.R., et al., 1996, Oncogene 13:1555-1559.
(3) Greenman C., et al., 2007, Nature 446:153-158.
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