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Recombinant human DPPIV /DPP4 /CD26 Protein, His Tag, 50µg  

Recombinant human DPPIV /DPP4 /CD26 Protein, His Tag, 50µg

Recombinant Human DPPIV /DPP4 /CD26 Protein, Asn29 - Pro766,  produced in human 293 cells (HEK293), His Tag

Recombinant Human Protein, DPP4, DPP-4, ADABP, ADCP2, ADCP-2, CD26, CD-26, DPPIV, DPPIV, TP103, TP-103

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Availability: within 7 days

408,00 €

Dipeptidyl peptidase-IV (DPPIV), also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides.(1) The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides.(2) DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1.(3) DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.(4) DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.

Human DPPIV, His Tag (DP4-H5221) is expressed from human 293 cells (HEK293). It contains AA Asp 34 - Pro 766 (Accession #NP_001926.2). Predicted N-terminus: Asp 34

Molecular Characterization
rhDPPIV, fused with a C-terminal 6×his tag and has a calculated MW of 85.4 kDa expressed. Protein migrates as 95 kDa in reduced SDS-PAGE resulting from glycosylation.

Less than 1.0 EU per μg of the rhDPPIV by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at:
In lyophilized state for 1 year (4C-8C); After reconstitution under sterile conditions for 1 month (4C-8C) or 3 months (-20C to -70C).


(1) Kameoka J, et al.,1993, Science, 261 (5120): 466-9.
(2) Chen X, 2006, Adv. Exp. Med. Biol. 575: 27–32.
(3) Morimoto, C. et al., 1994, Proc. Natl. Acad. Sci. USA. 91: 9960-4
(4) Havre PA, et al., 2008, Front. Biosci. 13: 1634–45