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Recombinant Human CD160/BY55 Protein, 2x500 ug  

Recombinant Human CD160/BY55 Protein, 2x500 ug

Recombinant Human CD160 /BY55 Protein, Ile 27 - Ser 159, produced in human 293 cells (HEK293), His Tag

Synonym
CD160, BY55, NK1, NK28

More details

BY5-H5229-1K

Availability: within 7 days

1 800,00 €

Background
CD160 antigen also known as natural killer cell receptor BY55, is a 27 kDa glycoprotein, contains 1 Ig-like V-type (immunoglobulin-like) domain. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. When expressed on vascular endothelial cells, CD160 propagates anti-angiogenic signals and promotes apoptosis.

Source
Recombinant Human CD160 /BY55 Protein (rhCD160) Ile 27 - Ser 159 (Accession # Accession # O95971-1) was produced in human 293 cells (HEK293).

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.7 kDa. The protein migrates as 25-28 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin
Less than 1.0 EU per μg of the rhCD160 by the LAL method.

Purity
>90% as determined by SDS-PAGE.

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

Reconstitution
See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Bioactivity
Please refer to product data sheet.

Clinical and Translational Updates

(1) "Attenuation of the BTLA/HVEM Regulatory Network in the Circulation in Primary Sjögren's Syndrome"
Small, Cole, Wang et al
J Clin Med (2022) 11 (3)
(2) "Identification of a DNA repair 9-gene signature for the overall survival prediction of pancreatic cancer"
Huang, Mao, Sun
Ann Diagn Pathol (2022) 57, 151883
(3) "The roles of risk model based on the 3-XRCC genes in lung adenocarcinoma progression"
Zhang, Yang, Yang et al
Transl Cancer Res (2021) 10 (10), 4413-4431
Showing 1-3 of 248 papers.