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Recombinant Mouse Fc gamma RI / CD64 Protein, His tag, 1mg  

Recombinant Mouse Fc gamma RI / CD64 Protein, His tag, 1mg

Recombinant Mouse Fc gamma RI / CD64 Protein (Glu 25 - Pro 297) was produced in human 293 cells, His tag

recombinant, mouse, protein, FCGR1A,FCG1,FCGR1,IGFR1,CD64,CD64A,FCRI

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Availability: within 7 days

1 800,00 €

Receptors that recognize the Fc portion of IgG are divided into three groups designated Fc gamma RI, RII, and RIII, also known respectively as CD64, CD32, and CD16. Fc gamma RI binds IgG with high affinity and functions during early immune responses. Fc gamma RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. High affinity immunoglobulin gamma Fc receptor I is also known as FCGR1A, FCG1, FCGR1, CD64 and IGFR1, is a type of integral membrane glycoprotein that binds monomeric IgG-type antibodies with high affinity, which belongs to the immunoglobulin superfamily or FCGR1 family. FCGR1A / CD64 contains 3 Ig-like C2-type (immunoglobulin-like) domains. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells.

Recombinant Mouse CD64 protein, His Tag (CD4-M5227) is expressed from human 293 cells (HEK293). It contains AA Glu 25 - Pro 297 (Accession # P26151-1). Predicted N-terminus: Glu 25

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 32.3 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg of the Mouse Fc gamma RI, His Tag by the LAL method.

>95% as determined by SDS-PAGE.

Please refer to product data sheet.

Please refer to data sheet.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C-8°C); After reconstitution under sterile conditions for 1 month (4°C-8°C) or 3 months (-20°C to -70°C).


(1) van Vugt M.J., et al., 1996, Blood 87:3593-3599.
(2) Ernst L.K., et al., 1998, Mol. Immunol. 35:943-954.
(3) van Vugt M.J., 1999, Blood 94:808-817.
(4) Edberg J.C., et al., 1999, J. Biol. Chem. 274:30328-30333.