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Recombinant Rhesus macaque EpCAM / TROP1 Protein, His Tag, 1 mg  

Recombinant Rhesus macaque EpCAM / TROP1 Protein, His Tag, 1 mg

Recombinant Rhesus macaque EpCAM / TROP1 Protein, Gln 24 - Lys 265, produced in human 293 cells (HEK293), His tag

recombinant, protein, rhesus macaque, EPCAM,TACSTD1,TROP1,CD326

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1 980,00 €

EpCAM is also known as CO171A,; EGP; EGP40; GA7332; KSA; M4S; MIC18; MK1; TROP1; hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.

Recombinant Rhesus macaque EpCAM / TROP1 Protein (Rhesus macaque EpCAM, His Tag) Gln 24 - Lys 265 (Accession # Q1WER1) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 28.2 kDa. The protein migrates as 33-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg of the Rhesus macaque EpCAM, His Tag by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).


(1) Linnenbach, et al., 1993, Mol Cell Biol 13 (3): 1507–15.
(2) Akita H, et al., 2011, Oncogene., 30 (31): 3468-76.
(3) Winter MJ, et al., 2007, Mol Cell Biochem. 302(1-2):19-26.
(4) Schmidt M, et al., 2011, Breast Cancer Res Treat. 125(3):637-46.

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