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Recombinant human CD200 / OX-2 Protein, His tag, 2 x 500µg  

Recombinant human CD200 / OX-2 Protein, His tag, 2 x 500µg

Recombinant Human CD200 / OX-2 Protein, Gln 31 - Gly 232, produced in human 293 cells (HEK293), His tag

recombinant, human, protein, CD200,MOX1,MOX2,MRC,OX-2,My033

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Availability: within 7 days

1 440,00 €

CD200 is also known as OX-2 membrane glycoprotein (OX-2), is a type-1 membrane glycoprotein, which contains two immunoglobulin domains (1 Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain), and thus belongs to the immunoglobulin superfamily. CD200 / OX-2 is widely expressed in multiple cell types. CD200 interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function. OX-2 / CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.

Recombinant Human CD200, His Tag (OX2-H5228) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Gly 232 (Accession # AAH22522). Predicted N-terminus: Gln 31

Molecular Characterization
Human CD200, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 23.4 kDa. The predicted N-terminus is Gln 31. The reducing (R) protein migrates as 35-45 kDa in SDS-PAGE due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>98% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).

Immobilized Human CD200, His Tag (Cat. No. OX2-H5228) at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD200 R1, Fc,Avitag (Cat. No. CR2-H82F4) with a linear range of 1-31 ng/mL (QC tested).


(1) McCaughan, G.W. et al., 1987, Immunogenetics 25:329-335.
(2) Chen, Z. et al., 2006, Mol Immunol. 43 (6): 579-587.
(3) Wright GJ., et al., 2003, J. Immunol. 171 (6): 3034–46.