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CDK inhibitor Aloisine, 5 mg  

CDK inhibitor Aloisine, 5 mg

CDK inhibitor Alosine, RP106, 7-n-Butyl-6-(4-methoxyphenyl)[5H]pyrrolo[2,3-b]pyrazine

Synonyms:  RP106
ATP-competitive inhibitor of Cdk1/B, Cdk5/p35 and GSK3, CAS number: 496864-15-4

 

More details

PKI-R106-005

Availability: on stock

125,00 €

Background: Aloisine is a potent, selective, cell-permeable and ATP-competitive inhibitor of Cdk1/B, Cdk5/p35 and GSK3 with IC50 values of 700nM, 1.5uM and 920nM, respectively.

Molecular weight: 281.4 g/mol
Solubility: soluble in DMSO and methanol
Chemical formula: C17H19N3O
Purity: > 98%
Appearance: off-white powder
CAS number: 496864-15-4

Product specific literature references:

Mettey Y, Gompel M, Thomas V, Garnier M, Leost M, Ceballos-Picot I, Noble M, Endicott J, Vierfond JM, Meijer L. (2003) "Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects." J Med Chem. 46(2):222-36.

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.   

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