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Indirubin-3\'-oxime, 10 mg  

Indirubin-3\'-oxime, 10 mg

3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

inhibitor of GSK-3beta

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PKI-INDO-010

Availability: within 3 days

265,00 €

Indirubin-3\'-oxime is a potent inhibitor of glycogen synthase kinase 3 beta (GSK-3beta), cyclin-dependent kinases Cdk1 and Cdk5 with IC50 values of 22, 80 and 100 nM, respectively. It also inhibits AMPK, LCK and SGK. Indirubin-3\'-oxime inhibits the proliferation of a large range of cells by arresting them in the G2/M phase of the cell cycle and inhibits Tau phosphorylation in vitro and in vivo at Alzheimer\'s disease-specific sites.

Chemical formula: C16H11N3O2
Molecular weight: 277.3 g/mol
Purity: > 98%
Appearance: Dark red solid
Solubility: soluble in DMSO and ethanol
CAS number: 160807-49-8

Product specific literature references:

Hoessel R, Leclerc S, Meijer L et al. (1999) "Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases" Nat. Cell Biol. 1(1):60-7

Fischer PM, Lane DP (2000) "Inhibitors of cyclin-dependent kinases as anti-cancer therapeutics" Curr. Med. Chem. 7(12):1213-45

Damiens E, Baratte B, Marie D, Eisenbrand G, Meijer L (2001) "Anti-mitotic properties of indirubin-3\'-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest" Oncogene 20(29):3786-97

Leclerc S, Garnier M, Meijer L et al. (2001) "Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer\'s disease. A property common to most cyclin-dependent kinase inhibitors?" J. Biol. Chem. 276(1):251-60

Marko D, Schatzle S, Friedel A, Genzlinger A, Zankl H, Meijer L, Eisenbrand G (2001) "Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells" Br. J. Cancer. 84(2):283-9

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.