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NU6102, 1 mg  

NU6102, 1 mg

O6-Cyclohexylmethyl-2-(4'-sulfamoylanilino)purine

Synonyms: NU 6102, NU-6102
specific inhibitor of CDK1/cyclin B and CDK2/cyclin A

More details

PKI-NU6102-001

Availability: within 3 days

125,00 €

Background: NU6102 is a specific inhibitor of CDK1/cyclin B (IC50 = 9.5 nM) and CDK2/cyclin A (IC50 = 9.5 nM). It is selective for CDK1 and CDK2 compared to CDK4/D1(IC50 = 1.6 µM), DYRK1A (IC50 = 0.9 µM), PDK1 (IC50 = 0.8 µM) and ROCKII (IC50 = 0.6 µM).
Chemical formula: C18H22N6O3S
Molecular weight: 402.5 g/mol
Purity: > 95%
Appearance: white solid
Solubility: soluble in DMSO
Handling: protect from light, toxic
CAS No. 444722-95-6

Product specific literature references:


Davies TG, Bentley J, Whitfield HJ (2002) "Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor" Nat Struct Biol. 9(10):745-9

Haesslein JL, Jullian N (2002) "Recent advances in cyclin-dependent kinase inhibition. Purine-based derivatives as anti-cancer agents. Roles and perspectives for the future" Curr Top Med Chem. 2(9):1037-50

Sayle KL, Bentley J, Griffin RJ (2003) "Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2" Bioorg Med Chem Lett. 13(18):3079-82

Hardcastle IR, Arris CE, Whitfield HJ (2004) "N2-substituted O6-cyclohexyl-methylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2" J Med Chem. 47(15):3710-22
PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.