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ActiveMax® Recombinant Human IL-2 Protein, 100 µg  

ActiveMax® Recombinant Human IL-2 Protein, 100 µg

ActiveMax® Recombinant Human IL-2 Protein, Ala 21 - Thr 153, produced in human 293 cells (HEK293), Tag free

Synonym: Recombinant Human Protein, IL2, lymphokine,Interleukin 2

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Availability: within 7 days

234,00 €

Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit crossspecies activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-regs). After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against "self antigens", which could result in "autoimmunity". T-Regs do so by preventing the responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system.

ActiveMax® Recombinant Human IL-2 Protein, Ala 21 - Thr 153 (Accession # P60568) was produced in human 293 cells (HEK293)

Molecular Characterization
This protein carries no "tag".
The protein has a calculated MW of 15.4 kDa. The protein migrates as 17 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH5.0. Normally Trehalose is added as protectant before lyophilization.

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). 

Immobilized Human IL-2, Tag Free (Cat. No. IL2-H4216) at 10μg/mL (100 μL/well) can bind Human IL-2 R beta, Fc Tag (Cat. No. ILB-H5253) with a linear range of 0.625-5 μg/mL (Routinely tested).
Request for protocol
Immobilized Human IL-2 R alpha, Fc Tag (Cat. No. ILA-H5251) at 2μg/mL (100 μL/well) can bind Human IL-2, Tag Free (Cat. No. IL2-H4216) with a linear range of 0.2-1.56 ng/mL (QC tested).
Request for protocol


(1) Gaffen, S.L. and K.D. Liu, 2004, Cytokine 28:109.
(2) Kasakura S, Lowenstein L, 1965, Nature 208 (5012): 794–795.
(3) Smith KA, Favata MF, Oroszlan S, 1983, J. Immunol. 131 (4): 1808.
(4) Thornton AM, Shevach EM, 1998, J. Exp. Med. 188 (2): 287–96.

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