kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
ActiveMax® Recombinant Human GFER /ALR, 20 µg  

ActiveMax® Recombinant Human GFER /ALR, 20 µg

Recombinant Human GFER /HPO Protein, ActiveMax, produced in human 293 cells (HEK293), Tag free

Synonym: Recombinant Human Protein, GFER,ALR,ERV1,HERV1,HPO,Hepatopoietin

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Availability: within 7 days

300,00 €

Growth factor, augmenter of liver regeneration (GFER) is also known as FAD-linked sulfhydryl oxidase ALR, which belongs to the Erv1/ALR family of proteins. This family can be found in higher and lower eukaryotes. There are two isoform of GFER: Isoform 1 and isoform 2. Isoform 2 missing 1 – 80 aa. Isoform 1 is mainly located in mitochondrion intermembrane space, while Isoform 1 is secreted to cytoplasm. Isoform 1 of GFER regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. The isoform 2 of GFER may act as an autocrine hepatotrophic growth factor promoting liver regeneration.

Recombinant Human GFER /HPO Protein,HEK293 expressed,ActiveMax (rh GFER) Met 81 - Asp 205 (Accession # NP_005253) was produced in human 293 cells (HEK293)

Molecular Characterization
rh GFER contains no "tag", and has a calculated MW of 15.2 kDa. The predicted N-terminus is Met 81. DTT-reduced Protein migrates as 16 kDa in SDS-PAGE .

Less than 1.0 EU per μg of the rh GFER by the LAL method.

>92% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).


(1) Daithankar V.N., et al., 2009, Biochemistry 48:4828-4837.
(2) Sztolsztener M.E., et al., 2013, Traffic 14:309-320.
(3) Di Fonzo A., et al., 2009, Am. J. Hum. Genet. 84:594-604.