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ActiveMax® Recombinant Mouse IFN-beta / IFNB1, 50 µg  

ActiveMax® Recombinant Mouse IFN-beta / IFNB1, 50 µg

ActiveMax® Recombinant Mouse IFN-beta / IFNB1, Ile 22 - Asn 182, produced in human 293 cells (HEK293), Tag free

Synonym: Recombinant Mouse Protein, IFNB1,Interferon beta,IFN-beta,IFB,IFNB

More details


Availability: within 7 days

420,00 €

Human type I interferons (IFNs) are a large subgroup of interferon proteins that help regulate the activity of the immune system. Interferons bind to interferon receptors. All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains. The IFN-β proteins are produced in large quantities by fibroblasts. They have antiviral activity that is involved mainly in innate immune response. Two types of IFN-β have been described, IFN-β1 (IFNB1) and IFN-β3 (IFNB3) (a gene designated IFN-β2 is actually IL-6). IFN-β1 is used as a treatment for multiple sclerosis as it reduces the relapse rate. Furthermore, IFN-β1 can bind to a IFNAR1-IFNAR2 heterodimeric receptor, and can also function with IFNAR1 alone and independently of Jak-STAT pathways.

ActiveMax® Recombinant Mouse IFN-beta / IFNB1 protein, Ile 22 - Asn 182 (Accession # P01575) was produced in human 293 cells (HEK293)

Molecular Characterization
ActiveMax® Recombinant Mouse IFN-beta contains no "tag", and has a calculated MW of 19.9 kDa. The reducing (R) protein migrates as 27-33 kDa in SDS-PAGE due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).


(1) de Weerd N.A., et al., 2013, Nat. Immunol. 14:901-907.
(2) Civas A., et al., 1988, Eur. J. Biochem. 173:311-316.