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Recombinant human CD48 / SLAMF2 Protein, 1mg  

Recombinant human CD48 / SLAMF2 Protein, 1mg

Recombinant human CD48 / SLAMF2 Protein, AA Gln 27 - Ser 220, expressed from human 293 cells (HEK293), His Tag

Synonym: recombinant human protein CD48,BCM1,SLAMF2,BLAST,BLAST1,MEM-102,TCT.1,BCM-1,SLAMF-2,BLAST-1

More details

BC1-H5226-1K

Availability: within 7 days

1 500,00 €

Background
CD48 antigen is also known as Signaling lymphocytic activation molecule 2, SLAM family member 2 (SLAMF2), Leukocyte antigen MEM-102, BCM1 surface antigen, B-lymphocyte activation marker BLAST-1. CD48 is a 65 kDa GPI-linked protein which belongs to the CD2 subfamily of immunoglobulin superfamily molecules. CD48 antigen contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domain. CD48 interacts with CD244 in an heterophilic manner. CD48 is ligand for CD2. CD48 might facilitate interaction between activated lymphocytes. CD48 is probably involved in regulating T-cell activation.

Source
Recombinant Human CD48, His Tag (BC1-H5226) is expressed from human 293 cells (HEK293). It contains AA Gln 27 - Ser 220 (Accession # AAH16182).
Predicted N-terminus: Gln 27

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 23.2 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin
Less than 1.0 EU per μg by the LAL method.

Purity
>95% as determined by SDS-PAGE.

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Bioactivity
Please refer to product data sheet:

Clinical and Translational Updates

(1) "Insights gained from Single-Cell analysis of immune cells on Cyclosporine A treatment in autoimmune uveitis"
Duan, Xie, Li et al
Biochem Pharmacol (2022) 202, 115116
(2) "Serum Biomarkers for Autoimmune Hepatitis Type 1: the Case for CD48 and a Review of the Literature"
Hu, You, Li et al
Clin Rev Allergy Immunol (2022)
(3) "Hoxb5 reprogrammes murine multipotent blood progenitors into haematopoietic stem cell-like cells"
Huang, Zhao, Zhang et al
Cell Prolif (2022) 55 (6), e13235
Showing 1-3 of 639 papers.