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Recombinant Human TIM-3 / HAVCR2 Protein, 1mg  

Recombinant Human TIM-3 / HAVCR2 Protein, 1mg

Recombinant Human TIM3 /HAVCR2 Protein His-Tag (rhTIM3 / HAVCR2) Ser 22 - Arg 200 was produced in human 293 cells (HEK293) (MALS verified)

Synonym: recombinant, human, protein, HAVCR2, HAVcr-2, KIM3, TIM3, TIMD-3, TIMD3, Tim-3, FLJ14428, KIM-3, KIM3

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Availability: within 7 days

1 980,00 €

Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

Recombinant Human TIM-3, His Tag (TM3-H5229) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Arg 200 (Accession # Q8TDQ0-1).
Predicted N-terminus: Ser 22

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 21.8 kDa. The protein migrates as 44-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg of the rhTIM3 / HAVCR2 by the LAL method.

>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

Please refer to product data sheet.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Clinical and Translational Updates

(1) "TIM-3 in Leukemia; Immune Response and Beyond"
Rezaei, Tan, Zeng et al
Front Oncol (2021) 11, 753677
(2) "Expression Levels of Three Key Genes CCNB1, CDC20, and CENPF in HCC Are Associated With Antitumor Immunity"
Si, Huang, Jiang et al
Front Oncol (2021) 11, 738841
(3) "Increased expression of programmed cell death ligand 1 and galectin 9 in transplant recipients who achieved tolerance after immunosuppression withdrawal"
Hai Nam, Taura, Koyama et al
Liver Transpl (2021)
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