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Recombinant Mouse CTLA-4 / CD152 Protein, Fc Tag , 1mg  

Recombinant Mouse CTLA-4 / CD152 Protein, Fc Tag , 1mg

Recombinant Mouse CTLA-4 / CD152 Protein, Fc Tag (Mouse CTLA-4 Protein, Fc Tag) Glu 36 - Phe 162 was produced in human 293 cells (HEK293).

Synonym:recombinant, mouse, protein, CTLA4,CD152,CELIAC3

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Availability: within 7 days

902,00 €

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

Recombinant Mouse CTLA-4, Fc Tag (CT4-M5256) is expressed from human 293 cells (HEK293). It contains AA Glu 36 - Phe 162 (Accession # NP_033973).
Predicted N-terminus: Glu 36

Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 40.6 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Please refer to product data sheet.

Clinical and Translational Updates

(1) "Activatable cancer sono-immunotherapy using semiconducting polymer nanobodies"
Zeng, Zhang, He et al
Adv Mater (2022)
(2) "Decreased Expression of Cytotoxic T Lymphocyte-associated Protein 4: A Risk Factor of Myocardial Infarction"
Mansouri, Seyed Mohammadzad
Iran J Allergy Asthma Immunol (2022) 21 (1), 86-91
(3) "Immune checkpoints in T cells during oncogenic γ-herpesvirus infections"
J Med Virol (2022)
Showing 1-3 of 11577 papers.


(1) "CTLA4‐Ig directly inhibits osteoclastogenesis by interfering with intracellular calcium oscillations in bone marrow macrophages"
Authors: Okada H, et al
Journal: J Bone Miner Res 43593
Application: Cell Culture


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