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Recombinant human ACVR1, protein kinase domain, 10 µg  

Recombinant human ACVR1, protein kinase domain, 10 µg

Recombinant human ACV-R1, protein kinase, amino acids A145-C509, (kinase domain), ACVR1

Alternate names: ACVR1, Activin A receptor, type I, SLK1, ALK2, ACVRLK2, ACVR-1 protein kinase

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465,00 €

Background: ACV-R1 is part of the BMP/TGFβ family, transmitting signals from TGFβ, BMPs or Activin through heteromeric complexes of transmembrane type I and type II serine/threonine kinase receptors. Both, type I and type II receptors are structurally very similar. They consist of a small cysteine-rich extracellular regions and intracellular parts formed mainly by the kinase domain. Typ I but not Typ II receptors carry a glycine and serine rich region (GS domain) in the juxtamembrane domain. Upon cytokine binding to the typ II receptor molecule the respective typ I receptor is recruited into the complex and activated by phosphorylation in the GS domain by associated typ II receptor. Activated typ I receptors in turn phosphorylate down-stream effectors, the receptor-activated Smads, which then translocate in the nucleus and regulate transcription processes. ACV-R1 or ALK2 was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or IIB. Recent studies revealed, that ALK2 is a BMP7 receptor

Activin A receptor, type I  (ACVR1 / ACV-R1), protein kinase domain (amino acids A145-C509), recombinant and active enzyme, N-terminally fused to GST-HIS6-Thrombin cleavage site

Theoretical MW: 71.534 kDa (fusion protein)
Expression system: Baculovirus infected Sf9 cells
Storage buffer: 50 mM Tris-HCl, pH 8.0; 100 mM NaCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol
Protein concentration: 0.391 mg/ml (Bradford method using BSA as standard protein)
Method for determination of Km value & specific activity: Filter binding assay MSPH membrane
Specific activity: 92,000 pmol/mg x min

Entrez Gene ID: 90
UniProtKB: Q04771

Ordering informations: shipped on dry ice

Product specific literature:

Matsuzaki K., McKeehan W.L. (1993) "A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor." J. Biol. Chem. 268:12719-12723

ten Dijke P., Ichijo H., Franzen P., Schulz P., Saras J., Toyoshima H., Heldin C.-H., Miyazono K. (1993) "Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity." Oncogene 8:2879-2887

Petrie K.A., Lee W.H., Bullock A.N., Pointon J.J., Smith R., Russell R.G., Brown M.A., Wordsworth B.P., Triffitt J.T. (2009) "Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients." PLoS ONE 4:E5005-E5005