kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
Recombinant human AXL, kinase domain, 10 µg  

Recombinant human AXL, kinase domain, 10 µg

Recombinant human protein receptor tyrosine kinase AXL, active enzyme, amino acids H464-A885 (kinase domain)

Alternate names: UFO, JTK11, tyrosine protein kinase receptor UFO, AXL receptor tyrosine kinase

More details


Availability: within 14 days

465,00 €

AXL protein kinase belongs to the TAM family comprising Tyro-3 (also called Sky), Axl, and Mer. TAM receptors are characterized by a unique structure combination of 2 immunoglobin-like domains and dual fibronectin type III repeats in the extracellular region and a cytoplasmic kinase domain. Overexpression or ectopic expression of the TAM receptors has been detected in human cancers. Abnormal expression and activation of Axl or Mer can provide a survival advantage for certain cancer cells.

Recombinant human AXL receptor tyrosine kinase, C-terminal fragment, amino acids H464-A885, recombinant and active enzyme, N-terminally fused to GST-HIS6-Thrombin cleavage site, expressed in Sf9 insect cells

Theoretical MW: 76.6 kDa (fusion protein)
Expression system: Baculovirus infected Sf9 cells
Storage buffer: 50 mM HEPES pH 7.5,100 mM NaCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol
Protein concentration: 0.228 mg/ml (Bradford method using BSA as standard protein)
Method for determination of Km value & specific activity: Filter binding assay MSFC membrane
Specific activity: 26,000 pmol/mg x min

Entrez Gene ID: 558 
UniProtKB:  P30530

Ordering informations: shipped on dry ice

Product specific literature:

Verma A, Warner SL, Vankayalapati H, Bearss DJ, Sharma S."Targeting Axl and Mer kinases in cancer."Mol Cancer Ther. 2011 Oct;10(10):1763-73. doi: 10.1158/1535-7163.MCT-11-0116