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LY294002, 5 mg  

LY294002, 5 mg

2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride

Synonyms: LY 294002, LY-294002, LY294,002
highly selective inhibitor of PI3 kinase

More details

PKI-LY294-005

Availability: within 3 days

125,00 €

Background: LY 294002 is a potent, cell permeable and highly selective inhibitor of phosphatidyl inositol 3 kinase (PI3K) displaying an IC50 value of 1.4 µM.

Chemical formula: C19H17NO3 . HCl
Molecular weight: 343.8 g/mol
Solubility: soluble in DMSO and ethanol
Appearance: White to off-white solid
Purity: >99%
CAS number: 154447-36-6

Product specific literature references:

Vlahos CJ, Matter WF, Hui KY, Brown RF (1994) "A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)" J. Biol. Chem. 269(7):5241-8

Sanchez-Margalet V, Goldfine ID, Vlahos CJ, Sung CK (1994) "Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002" .Biochem. Biophys. Res. Commun. 204(2):446-52

Yano H, Agatsuma T, Nakanishi S, Saitoh Y, Fukui Y, Nonomura Y, Matsuda Y (1995) "Biochemical and pharmacological studies with KT7692 and LY294002 on the role of phosphatidylinositol 3-kinase in Fc epsilon RI-mediated signal transduction" Biochem J. 312 ( Pt 1):145-50

Rosenzweig KE, Youmell MB, Palayoor ST, Price BD (1997) "Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay" Clin Cancer Res. 3(7):1149-56

Chasserot-Golaz S, Hubert P, Thierse D, Dirrig S, Vlahos CJ, Aunis D, Bader MF (1998) "Possible involvement of phosphatidylinositol 3-kinase in regulated exocytosis: studies in chromaffin cells with inhibitor LY294002" J. Neurochem. 70(6):2347-56

Casagrande F, Bacqueville D, Pillaire MJ, Malecaze F, Manenti S, Breton-Douillon M, Darbon JM (1998) "G1 phase arrest by the phosphatidylinositol 3-kinase inhibitor LY 294002 is correlated to up-regulation of p27Kip1 and inhibition of G1 CDKs in choroidal melanoma cells" FEBS Lett. 422(3):385-90

Salh B, Wagey R, Marotta A, Tao JS, Pelech S (1998) "Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production" J Immunol. 161(12):6947-54

Gallis B, Corthals GL, Corson MA et al. (1999) "Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002" J. Biol. Chem. 274(42):30101-8

Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP, Williams RL (2000) "Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine" Mol. Cell 6(4):909-19

Hu L, Zaloudek C, Mills GB, Gray J, Jaffe RB (2000) "In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002)" Clin Cancer Res. 6(3):880-6

Adi S, Wu NY, Rosenthal SM (2001) "Growth factor-stimulated phosphorylation of Akt and p70(S6K) is differentially inhibited by LY294002 and Wortmannin" Endocrinology 142(1):498-501

El-Kholy W, Macdonald PE, Lin JH, Wang J, Fox JM, Light PE, Wang Q, Tsushima RG, Wheeler MB (2003) "The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism" FASEB J. 17(6):720-2

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.