Biaffin

Newsletter

kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
Phloretin, 250 mg  

Phloretin, 250 mg

2′,4′,6′-Trihydroxy-3-p-hydroxyphenylpropiophenone

inhibitor of PKC and a PGF2a receptor antagonist

More details

PKI-PHLRTN-250

Availability: on stock

80,00 €

Background: Phloretin is a cell-permeable protein kinase C (PKC) inhibitor (IC50 = 20-50 µM) and a PGF2a receptor antagonist. In astrocytes, these receptors are linked to phospholipase C, thus affecting phosphoinositide hydrolysis and intracellular Ca2+ levels. It inhibits L-type Ca2+ channel activity. Phloretin also inhibits myo-inositol uptake and serve as a potent inhibitor of 5'-iodothyronine deiodinase.

Chemical formula: C15H14O5
Molecular Weight: 274.3 g/mol
Purity: >98%
Appearance: White solid
Solubility: soluble in Ethanol, Methanol or Acetone
CAS number: 60-82-2

Product specific literature references:

Nelson JA, Falk RE (1993) "The efficacy of phloridzin and phloretin on tumor cell growth" Anticancer Res. 13(6A):2287-92

Kitanaka J, Ishibashi T, Baba A. (1993) "Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes" J. Neurochem 60(2):704-8

Wang X, Poole RC, Halestrap AP, Levi AJ.. (1993) "Characterization of the inhibition by stilbene disulphonates and phloretin of lactate and pyruvate transport into rat and guinea-pig cardiac myocytes suggests the presence of two kinetically distinct carriers in heart cells :" Biochem J. 290 ( Pt 1):249-58

Koh DS, Reid G, Vogel W. (1994) "Activating effect of the flavonoid phloretin on Ca(2+)-activated K+ channels in myelinated nerve fibers of Xenopus laevis" Neurosci Lett. 165(1-2):167-70

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.