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Background: Phloretin is a cell-permeable protein kinase C (PKC) inhibitor (IC50 = 20-50 µM) and a PGF2a receptor antagonist. In astrocytes, these receptors are linked to phospholipase C, thus affecting phosphoinositide hydrolysis and intracellular Ca2+ levels. It inhibits L-type Ca2+ channel activity. Phloretin also inhibits myo-inositol uptake and serve as a potent inhibitor of 5'-iodothyronine deiodinase.
Chemical formula: C15H14O5
Molecular Weight: 274.3 g/mol
Purity: >97%
Appearance: White solid
Solubility: soluble in Ethanol, Methanol or Acetone
CAS number: 60-82-2
Nelson JA, Falk RE (1993) "The efficacy of phloridzin and phloretin on tumor cell growth" Anticancer Res. 13(6A):2287-92
Kitanaka J, Ishibashi T, Baba A. (1993) "Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes" J. Neurochem 60(2):704-8
Wang X, Poole RC, Halestrap AP, Levi AJ.. (1993) "Characterization of the inhibition by stilbene disulphonates and phloretin of lactate and pyruvate transport into rat and guinea-pig cardiac myocytes suggests the presence of two kinetically distinct carriers in heart cells :" Biochem J. 290 ( Pt 1):249-58
Koh DS, Reid G, Vogel W. (1994) "Activating effect of the flavonoid phloretin on Ca(2+)-activated K+ channels in myelinated nerve fibers of Xenopus laevis" Neurosci Lett. 165(1-2):167-70
PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.
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