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Recombinant human Activin RIIB / ACVR2B Protein, His tag, 2x 500µg  

Recombinant human Activin RIIB / ACVR2B Protein, His tag, 2x 500µg

Recombinant human Activin RIIB / ACVR2B Protein, Ser19-Thr137, produced in human 293 cells (HEK293), His Tag

Recombinant human Protein, ACVR2B, ACTRIIB, ACTR?B, ActR-IIB, ACTR-IIB, MGC116908, Activin receptor type-2B

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1 100,00 €

Activin receptor type-2B (ACVR2B),is also known as ActR-IIB and MGC116908, ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4).[1,2]

Human Activin RIIB, His Tag (ACB-H5226) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Thr 137 (Accession # NP_001097).
Predicted N-terminus: Ser 19

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 14.5 kDa. The protein migrates as 25-40 kDa under reducing (R) condition (SDS-PAGE).

Less than 1.0 EU per µg of the rhACVR2B by the LAL method.

>97% as determined by SDS-PAGE.

Lyophilized from 0.22 µm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C-8°C); After reconstitution under sterile conditions for 1 month (4°C-8°C) or 3 months (-20°C to -70°C).

N / A


(1) Attisano, L. et al., 1996, Mol. Cell. Biol. 16: 1066-1073.
(2) Woodruff, T.K. (1998) Biochem. Pharmacology 55:953 .