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SB202190, 10 mg  

SB202190, 10 mg

4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol

Synonyms: SB 202190, SB-202190
potent and cell permeable inhibitor of p38 MAP kinases

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PKI-SB202-010

Availability: within 3 days

143,00 €

Background: SB202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinases. It binds within the ATP pocket of the active kinase with a Kd of 38 nM as measured in recombinant human p38. SB202190 selectively inhibits the p38alpha and beta isoforms (IC50 values are 50 and 100 nM for p38alpha/SAPK2alpha and p38beta/SAPK2beta respectively).

Chemical formula: C20H14N3OF
Molecular weight: 331.4 g/mol
Purity: >98%
Solubility: soluble in DMSO
CAS Number: 152121-30-7

Product specific literature references:

Nemoto S, Xiang J, Huang S, Lin A (1998) "Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase" J. Biol. Chem. 273(26):16415-20

Manthey CL, Wang SW, Kinney SD, Yao Z (1998) "SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes" J. Leukoc. Biol. 64(3):409-17

Frantz B, Klatt T, Pang M, Parsons J, Rolando A, Williams H, Tocci MJ, O\'Keefe SJ, O\'Neill EA (1998) "The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding" Biochemistry 37(39):13846-53

Davies SP, Reddy H, Caivano M, Cohen P (2000) "Specificity and mechanism of action of some commonly used protein kinase inhibitors" Biochem. J. 351(Pt 1):95-105

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.