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CK2 peptide substrate 2, 1 mg  

CK2 peptide substrate 2, 1 mg

CK2 peptide substrate 2 (sequence: RRRADDSDDDDD)

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150,00 €

The synthetic peptide RRRADDSDDDDD can be used as a substrate for protein kinase CK2 alpha subunit or holoenzyme in in vitro kinase assays. It is phosphorylated by CK2 holoenzyme with a Km of 20 µM and a Vmax of 232.1 nmol/min/mg.

CK2 substrate peptide 2:    order-no. PEP-CK2II-001
Amino acid sequence.:       RRRADDSDDDDD (12-mer)
Molecular Weight:              1450 g/mol
Shipment conditions:          Ambient temperature
Long Term Storage:           -20°C (AVOID FREEZE/THAW CYCLES)
Purity:                                 90-95% (by HPLC)
Appearance:                       Lyophilized solid
Reconstitution:                    1 mg in 1.725 ml water dest. results in a 400 µM solution

Product specific literature references:

Meggio F, Marin O, Pinna LA. (1994) Substrate specificity of protein kinase CK2. Cell Mol Biol Res 40, 401-9

Bosc DG, Luscher B, Litchfield DW (1999) "Expression and regulation of protein kinase CK2 during the cell cycle" Mol Cell Biochem. 191(1-2):213-22

McKendrick L, Milne D, Meek D (1999) "Protein kinase CK2-dependent regulation of p53 function: evidence that the phosphorylation status of the serine 386 (CK2) site of p53 is constitutive and stable" Mol Cell Biochem. 191(1-2):187-99

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.  

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