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H-89, 10 mg  

H-89, 10 mg

PKA inhibitor H-89, N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide . 2HCl

Synonyms: H89, H 89, potent and inhibitor of PKA, PKG and PKCµ, CAS number: 130964-39-5

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PKI-H089-010

Availability: on stock

190,00 €

Background: Cell permeable potent and selective inhibitor of cAMP-dependent protein kinase (PKA, IC50 ~50 nM), cGMP-dependent protein kinase (PKG) and protein kinase Cµ (PKCµ). In contrast, most other protein kinase C (PKC) isotypes are much more weakly inhibited. Also inhibits ROCKII, Ca2+/calmodulin dependent protein kinase II (CaMKII), casein kinase I (CKI) and myosin light chain kinase (MLCK). Induces apoptosis.

Chemical formula: C20H20BrN3O2S . 2HCl
Molecular weight: 446.4 + 73.0 g/mol
Purity: > 98%
Appearance: powder
Solubility: soluble in 100% ethanol, DMSO and water
CAS number: 130964-39-5

Product specific literature references:

Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inoue T, Naito K, Toshioka T, Hidaka H. (1990) "Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP dependent protein kinase, N-[2-(p-bromocinnamylamino) ethyl]- 5-isoquinoline sulfonamide (H-89), of PC12D pheochromocytoma cells." J. Biol. Chem. 265(9):5267-72

Geilen CC, Wieprecht M, Wieder T, Reutter W. "A selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-bromocinnamyl (amino)ethyl] 5-isoquinoline sulfonamide (H-89), inhibits phosphatidylcholine biosynthesis in HeLa cells" (1992) FEBS Lett. 309(3):381-4.

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.