kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
HA-1004, 10 mg  

HA-1004, 10 mg

N-(2'-Guanidinoethyl)-5-isoquinolinesulfonamide dihydrochloride

Synonyms: HA1004
inhibitor of PKG and PKA and at higher concentrations of PKC and MLCK

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Availability: on stock

170,00 €

Background: Inhibitor of cAMP- and cGMP-dependent kinases (PKA/PKG, IC50 ~1-2uM). Also inhibits CaMKII, PKC and MLCK at higher concentrations. Intracellular Ca2+ antagonist with no effect on cardiac function. Causes selective pulmonary vasodilation during pulmonary hypertension.

Chemical formula: C12H15N5O2S . 2HCl
Molecular weight: 293.3 + 73.0 g/mol
Purity: > 98%
Form: solid
Solubility: soluble in water
CAS number: 92564-34-6

Also available predissolved at 10 mM in our kinase inhibitor Set (AGC group).

Product specific literature references:

Crowley MR, Fineman JR, Soifer SJ. (1994) "HA1004, an intracellular calcium antagonist, selectively attenuates pulmonary hypertension in newborn lambs." J. Cardiovasc. Pharmacol. (5):806-13

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.