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Background: Inhibitor of cAMP- and cGMP-dependent kinases (PKA/PKG, IC50 ~1-2uM). Also inhibits CaMKII, PKC and MLCK at higher concentrations. Intracellular Ca2+ antagonist with no effect on cardiac function. Causes selective pulmonary vasodilation during pulmonary hypertension.
Chemical formula: C12H15N5O2S . 2HCl
Molecular weight: 293.3 + 73.0 g/mol
Purity: > 98%
Form: solid
Solubility: soluble in water
CAS number: 92564-34-6
Also available predissolved at 10 mM in our kinase inhibitor Set (AGC group).
Crowley MR, Fineman JR, Soifer SJ. (1994) "HA1004, an intracellular calcium antagonist, selectively attenuates pulmonary hypertension in newborn lambs." J. Cardiovasc. Pharmacol. (5):806-13
PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.
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