kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
H-7, 10 mg  

H-7, 10 mg

1-(5-Isoquinolinesulfonyl)-2-methylpiperazine . 2HCl

Synonyms: H7, H7 dihydrochloride, isoquinolinesulfonyl protein kinase inhibitor, inhibitor of PKC, PKA and PKG and MLCK, CAS number: 108930-17-2

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Background: H-7 is an inhibitor of protein kinase C (PKC), cAMP- and cGMP-dependent protein kinase (PKA and PKG) and also inhibits myosin light chain kinase (MLCK). It induces apoptotic DNA fragmentation and cell death and inhibits telomerase activity in treated NPC-076 cells.

Chemical formula: C14H17N3O2S . 2 HCl
Molecular weight: 291.4 + 73.0 g/mol
Purity: > 95%
Solubility: soluble in water
Appearance: powder
CAS number: 108930-17-2

Product specific literature references:

Hidaka H, Inagaki M, Kawamoto S, Sasaki Y. (1984) "Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C." Biochemistry. 23(21):5036-41.

Kawamoto S, Hidaka H (1984) "1-(5-Isoquinolinesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase C in rabbit platelets" Biochem. Biophys. Res. Commun. 125(1):258-64

Schachtele C, Seifert R, Osswald H (1988) "Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine" Biochem. Biophys. Res. Commun. 151(1):542-7

Engh RA, Girod A, Kinzel V, Huber R, Bossemeyer D. (1996) "Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity." J. Biol. Chem. 271(42):26157-64.

Ku WC, Cheng AJ, Wang TC (1997) "Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture" Biochem. Biophys. Res. Commun. 241(3):730-6

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.