
- Remove this product from my favorite's list.
- Add this product to my list of favorites.
Products
Newsletter
![]() | ![]() | ![]() | ![]() | ![]() | ![]() |
Background: Potent inhibitor of cGMP-dependent protein kinase (PKG, IC50 ~500nM) and cAMP-dependent protein kinase (PKA, IC50 ~1200nM). Also inhibits myosin light chain kinase (MLCK).
Formula: C12H15N3O2S . 2HCl
Molecular weight: 265.3 + 73.0 g/mol
Purity: > 95%
Appearance: powder
Solubility: soluble in water and DMSO
CAS number: 113276-94-1
Also available predissolved at 10 mM in our kinase inhibitor Set (AGC group).
Hidaka H, Inagaki M, Kawamoto S, Sasaki Y. (1984) "Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C." Biochemistry. 23(21):5036-41.
Hagiwara M, Inagaki M, Hidaka H. (1987) "Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase." Mol Pharmacol. 31(5):523-8
Engh RA, Girod A, Kinzel V, Huber R, Bossemeyer D. (1996) "Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity." J. Biol. Chem. 271(42):26157-64.
PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.
Welcome Login
Contact us
Follow us