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MAPK Inhibitor Set, 5x 50 µl  

MAPK Inhibitor Set, 5x 50 µl

contains SL327, U0126, SP600125, PD98059 and SB203580
predissolved in DMSO (10 mM)

More details

PKI-MAPKSET-250

Availability: on stock

245,00 €

Set contains inhibitors which target components of MAPK pathway (SL327, U0126, SP600125PD98059 and SB203580). The products are predissolved in DMSO at a stock concentration of 10 mM in 50 µl. 

Ordering information: shipped on dry ice

Product specific literature references:

Peggy A. Scherle, Wen-ge Ma, Hyunjung Lim, Sudhansu K. Dey, and James M. Trzaskos. (2000) "Regulation of Cyclooxygenase-2 Induction in the Mouse Uterus During Decidualization ." J. Biol. Chem.,275. 47, 37086-37092

Bennett BL, Sasaki DT, Anderson DW et al. (2001) "SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase" Proc Natl Acad Sci U S A. 98(24):13681-6

Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR (1995) "PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo" J. Biol. Chem. 270(46):27489-94

Barone FC, Irving EA, Ray AM, Lee JC, Kassis S, Kumar S, Badger AM, White RF, McVey MJ, Legos JJ, Erhardt JA, Nelson AH, Ohlstein EH, Hunter AJ, Ward K, Smith BR, Adams JL, Parsons AA.. (2001) " SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia J Pharmacol Exp Ther. 296(2):312-21.

Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, Young PR, Lee JC. (1995) "SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1." FEBS Lett. 364(2):229-33
English JM, Cobb MH. (2002) "Pharmacological inhibitors of MAPK pathways" Trends Pharmacol Sci.  23(1):40-5

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.