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Src Family Inhibitor Set, 5x 50 µl  

Src Family Inhibitor Set, 5x 50 µl

contains Aminogenistein, PP1, PP2, SU6656, Src Inhibitor No.5
predissolved in DMSO at a stock concentration of 10 mM in 50 µl

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PKI-SRCSET-250

Availability: on stock

245,00 €

Set contains inhibitors which are specific for the Src family of tyrosine kinases (Aminogenistein, PP1, PP2, SU6656, Src Inhibitor No.5). The products are predissolved in DMSO at a stock concentration of 10 mM in 50 µl. 

Ordering information: shipped on dry ice

Product specific literature:

Mark Cushman, Dhanapalan Nagarathnam, Debra L. Burg, and Robert L. Geahlen (1991) "Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogs " J Med Chem. 34(2): 798 - 806

Hanke JH, Gardner JP, Dow RL, Changelian PS, Brissette WH, Weringer EJ, Pollok BA, Connelly PA (1996) "Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation" J. Biol. Chem. 271(2):695-701.

Amoui M, Draber P, Draberova L (1997) "Src family-selective tyrosine kinase inhibitor, PP1, inhibits both Fc epsilonRI- and Thy-1-mediated activation of rat basophilic leukemia cells" Eur. J. Immunol. 27(8):1881-6

Krystal GW, DeBerry CS, Linnekin D, Litz J (1998) "Lck associates with and is activated by Kit in a small cell lung cancer cell line: inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1" Cancer Res. 58(20):4660-6

Hanke JH, Gardner JP, Dow RL, Changelian PS, Brissette WH, Weringer EJ, Pollok BA, Connelly PA (1996) "Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation" J. Biol. Chem. 271(2):695-701.

Blake RA, Broome MA, Liu X, Wu J, Gishizky M, Sun L, Courtneidge SA (2000) "SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling" Mol. Cell. Biol. 20(23):9018-27

Ple PA, Green TP, Hennequin LF, Curwen J, Fennell M, Allen J, Lambert-Van Der Brempt C, Costello G. (2004) "Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src." J Med Chem. 12;47(4):871-87.

Boschelli DH, Wang YD, Johnson S, Wu B, Ye F, Barrios Sosa AC, Golas JM, Boschelli F. (2004) "7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases." J Med Chem. 47(7):1599-601.

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.