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Receptor tyrosine kinase inhibitor GTP 14564, 10 mg  

Receptor tyrosine kinase inhibitor GTP 14564, 10 mg

Inhibitor of class III receptor tyrosine kinases, 3-Phenyl-1H-benzofuro[3,2-c]pyrazole

Synonyms: GTP14564, selective inhibitor of class III receptor tyrosine kinases (FLT3, PDGFR, c-Kit), CAS number: 34823-86-4

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295,00 €

Background: GTP 14564 is a potent and selective inhibitor of class III receptor tyrosine kinases (IC50 values are 0.3 μM for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μM for PDGFRβ) and does not affect the  activity of other kinases (IC50 values for KDR, EGFR, HER2, ERK1, ERK2, MEK1, Src, PKA, PKC and AKT are > 10 µM). Whereas GTP-14564 inhibits the kinase activities of both wt-FLT3 and ITD-FLT3 with a similar efficiency it shows a selective cytotoxicity on ITD-FLT3 induced cells than on its wild type counterpart.

Purity: > 99%
Solubility: DMSO 
Molecular Weight:  234.26 g/mol
Formula: C15H10N2O
CAS number: 34823-86-4

Product specific literature references:

Yao Q, Nishiuchi R, Kitamura T, Kersey JH. (2005) "1: Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway." Leukemia. 19(9):1605-12.

Murata K, Kumagai H, Kawashima T, Tamitsu K, Irie M, Nakajima H, Suzu S, Shibuya M, Kamihira S, Nosaka T, Asano S, Kitamura T. (2003) "Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3)." J Biol Chem. 278(35):32892-8.

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers. 

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