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TCS PIM1-4a, 10 mg  

TCS PIM1-4a, 10 mg

(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiaz olidinedione

potent ATP competitive inhibitor of PIM-1 and PIM-2

More details

PKI-TCS-010

215,00 €

Background: Pim protein kinases are receiving increasing attention because of their roles in prostate cancer and leukemias. TCS PIM1-4a is a potent ATP competitive inhibitor of PIM-1 and PIM-2 (IC50 values are 24 and 100 nM). The compound shows cytotoxicity toward PC3 prostate carcinoma cells at high concentrations (IC50 = 17 µM).

Chemical formula: C11H6F3NO2S
Molecular Weight: 273.23 g/mol
Purity: >98%
Appearance: off white solid
solubility: soluble in DMSO (100 mM)
CAS Number : 438190-29-5

Product specific literature references:

Xia Z, Knaak C, Ma J, Beharry ZM, McInnes C, Wang W, Kraft AS, Smith CD. (2009) " Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.” J Med Chem. 8;52(1):74-86.
  

Xia Z, Knaak C, Ma J, Beharry ZM, McInnes C, Wang W, Kraft AS, Smith CD. (2009) " Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.” J Med Chem. 8;52(1):74-86.