kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
PKB / AKT inhibitor 10-DEBC hydrochloride, 10 mg  

PKB / AKT inhibitor 10-DEBC hydrochloride, 10 mg

inhibitor of protein kinase Akt / PKB, 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride

10-DEBC hydrochloride, CAS No. 201788-90-1

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Background: 10-DEBC hydrochloride is a selective inhibitor of protein kinase Akt / PKB. It inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 µM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein.

Chemical name: 10-[4\'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride
Formula: C20H25N2OCl. HCl 
Molecular Weight:   381.34 g/mol
Purity: >99 %
Appearance: Off white solid
Solubility: Water to 100 mM, DMSO to 100 mM

CAS No.                      201788-90-1

PLEASE NOTE: Our highly pure research chemicals are provided only to academic and business customers for research use. This product has not been approved for any other purposes including, without limitation, diagnostic or therapeutic purposes, for use in preparation of food or pharmaceutical products nor for administration to humans. We do not supply private customers or non-research organizations with this product.

Product specific literature:

Thimmaiah KN, Horton JK, Seshadri R, Israel M, Houghton JA, Harwood FC, Houghton PJ. (1992) "Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells." J.Med.Chem. 35(18):3358-64

Thimmaiah KN, Easton JB, Germain GS, Morton CL, Kamath S, Buolamwini JK, Houghton PJ. (2005) "Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling." J. Biol. Chem. 280(36):31924-35.