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AKT protein kinase inhibitor Deguelin, 5 mg  

AKT protein kinase inhibitor Deguelin, 5 mg

(7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H,7aH-pyrano[2,3-c;6,5-f']dichromen-7-one

Deguelin is an inhibitor of activated Akt, protein kinase inhibitor

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PKI-DEG-005

Availability: within 3 days

161,50 €

Background: Deguelin is an inhibitor of activated Akt. Anticancer, chemopreventive agent. Inhibits PI 3-kinase and reduces pAkt levels in pre-malignant and malignant human bronchial epithelial cells. Active in vivo.

Chemical formula: C23H22O6
Molecular weight: 394.42 g/mol
Purity: >98%
Appearance: Off-white solid
Solubility: Soluble in DMSO and Ethanol
CAS Number: 522-17-8

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.  

References


AS Nair et al. Deguelin, an Akt Inhibitor, Suppresses IKBa Kinase Activation Leading to Suppression of NF-KB-Regulated Gene Expression, Potentiation of Apoptosis, and Inhibition of Cellular Invasion. J. Immunol. 2006, 177, 5612-5622.
 
KH Chun et al. Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J. Natl. Cancer Inst. 2003, 95, 291-302.