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B-RAF protein kinase inhibitor PLX 4720, 2 mg  

B-RAF protein kinase inhibitor PLX 4720, 2 mg

Propane-1-sulfonic acid [3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide

PLX4720 is a selective inhibitor of protein kinase, targeting B-Raf (V600E)

More details

PKI-PLX4720-002

Availability: within 3 days

97,50 €

Background: PLX4720 is a selective inhibitor of protein kinase, targeting B-Raf (V600E) with IC50 of 13 nM in a cell-free assay.

Chemical name
Propane-1-sulfonic acid [3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide

Chemical formula: C17H14ClF2N3O3S
Molecular weight: 413.83 g/mol
Purity: >99%
Appearance: White solid
Solubility: soluble in DMSO
CAS Number: 918505-84-7
Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.

References

J Tsai et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci USA. 2008, 105(8), 3041-3046.