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ALK protein kinase inhibitor A 83-01, 5 mg  

ALK protein kinase inhibitor A 83-01, 5 mg

3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide

A 83-01 is a potent inhibitor of TGF-β type I receptor superfamily

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PKI-A8301-005

Availability: within 3 days

110,50 €

Background: A 83-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 and its relatives ALK4 and ALK7 (IC50 to be 12, 45 and 7.5 nM respectively). A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β, but had no effect on BMP signaling; Used to generate rat and human iPS cells towards a mouse ES cell like self-renewal state.

*Note: A 83-01 is found to decompose to A 77-01 in solution slowly. Hence freshly prepared solution is highly recommended and otherwise, its stock solution in DMSO needs to be stored <-20 °C (not longer than 1 month).

Chemical name
5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-pyperidinyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-Pyrimidinediamine

Chemical formula: C25H19N5S
Molecular weight: 421.52 g/mol
Purity: >99%
Appearance: Pale-yellow Solid
Solubility: soluble in DMSO
CAS Number: 909910-43-6

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers. 

References

M Tojo et al. The ALK5 inhibitor A-83-01 inhibits smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β. Cancer. Sci. 2005, 96, 791-800.

W. Li et al. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 2009, 4, 16-19.