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Aurora A kinase Inhibitor II, 5 mg  

Aurora A kinase Inhibitor II, 5 mg

4-(2-(4-(2-(4-acetylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)-N-(2-chlorophenyl)benzamide

Aurora A inhibitor II is a potent and selective inhibitor of Aurora A kinase (AurA)

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PKI-AURA2-005

Availability: within 3 days

182,00 €

Background: Aurora A kinase inhibitor II is a potent and selective inhibitor of Aurora A kinase (AurA), with IC50 values to be 4.3 nM (Aurora A) and unusually high selectivity 860 fold against Aurora B; a useful tool compound for investigating the cellular role of Aurora A kinases.

Chemical formula: C31H29ClFN7O3
Molecular weight: 602.06 g/mol
Purity: >99%
Solubility: Soluble in DMSO
Appearance: White solid
CAS Number: 1158838-43-7

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers. 

References

I Aliagas-Martin et al. A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J. Med. Chem. 2009, 52(10), 3300-7.

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