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AKT protein kinase inhibitor GSK 690693, 5 mg  

AKT protein kinase inhibitor GSK 690693, 5 mg

(S)-4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol

GSK 690693 is an ATP-competitive Akt kinase inhibitor

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PKI-GSK690-005

Availability: within 3 days

172,50 €

Background: GSK 690693 is a potent and ATP-competitive Akt kinase inhibitor, with IC50 to be 2, 13 and 9 nM for Akt1, Akt2 and Akt3 respectively. GSK690693 is very selective for the Akt isoforms versus the majority of kinases in other families.

Chemical formula: C21H27N7O3
Molecular weight: 425.48 g/mol
Purity: >99%
Solubility: Soluble in DMSO
Appearance: Pale yellow solid
CAS Number: 937174-76-0

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers. 

References

N Rhodes et al. Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity. Cancer Res. 2008, 68(7), 2366-2374.

DA Heerding et al. Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J. Med. Chem. 2008, 51(18), 5663-5679.

DS Lew et al. AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. Blood. 2009, 113(8), 1723-1729.

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