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Aurora protein kinase inhibitor AMG 900, 5 mg  

Aurora protein kinase inhibitor AMG 900, 5 mg

N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine

AMG 900 is a pan-aurora protein kinases inhibitor

More details

PKI-AMG900-005

Availability: within 3 days

169,00 €

Background: AMG 900 is a potent and highly selective inhibitor of pan-aurora kinases with activity in taxane-resistant tumor cell lines (IC50 Aurora A: 5 nM; Aurora B: 4 nM; Aurora C: 1 nM) . It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2

Chemical formula: C28H21N7OS
Molecular weight: 503.58 g/mol
Purity: >98%
Solubility: Soluble in DMSO
Appearance: Yellow Solid
CAS Number: 945595-80-2

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers. 

References

MN Payton et al. Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Cancer Res. 2010, 70(23), 9846-9854.

L Huang et al. In vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases. Xenobiotica. 2011, 41(5), 400-408.

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