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ALK5 protein kinase inhibitor GW 788388, 10 mg  

ALK5 protein kinase inhibitor GW 788388, 10 mg

4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide

GW 788388 is a inhibitor of activin receptor-like kinase 5, (ALK5)

More details

PKI-GW788-010

Availability: within 3 days

136,50 €

Background: GW 788388 is a potent, orally active and selective inhibitor of transforming growth factor β receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5). Furthermore, GW788388 inhibits  ALK4, ALK7 and TGF-β-mediated growth arrest.

Chemical formula: C25H23N5O2
Molecular weight: 425.48 g/mol
Purity: >99%
Solubility: Soluble in DMSO
Appearance: White Solid
CAS Number: 452342-67-5

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.  

References

SM Tan et al. Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 2010, 298, H1415-1425.

F Gellibert et al. Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor (...). J. Med. Chem. 2006, 49(7), 2210-2221.

M Petersen et al. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int. 2008, 73(6), 705-15.

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