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AKT protein kinase inhibitor AZD 5363 dihydrochloride, 5 mg  

AKT protein kinase inhibitor AZD 5363 dihydrochloride, 5 mg

(S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide dihydrochloride

AZD 5363 dihydrochloride potently inhibits all isoforms of Akt protein kinase

More details

PKI-AZD5363-005

Availability: within 3 days

172,50 €

Background: AZD 5363 dihydrochloride is an orally bioavailable, selective and potent protein kinase B (Akt) inhibitor in low nM potency (with IC50 for AKT1: 3 nM; AKT2: 8 nM and AKT3: 8 nM).  AZD5363 dihydrochloride is directly water-soluble.

Chemical formula: C21H25ClN6O2.2HCl
Molecular weight: 501.84 g/mol
Purity: >99%
Solubility: Soluble in water and DMSO
Appearance: Off-white solid
CAS Number: 1143532-39-1

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.  

References

BR Davies et al. Preclinical Pharmacology of AZD5363, an Orally Bioavailable Inhibitor of AKT: Pharmacodynamics, Antitumor Activity and Correlation of Monotherapy Activity with Genetic Background. Mol. Cancer Ther. 2012, 11(4), 873-887.
Addie M, et al. J Med Chem, 2013, 26.

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