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CDK4 protein kinase inhibitor NSC 625987, 10 mg  

CDK4 protein kinase inhibitor NSC 625987, 10 mg

1,4-Dimethoxy-10H-acridine-9-thione

NSC 625987 is a selective and potent cyclin-dependent kinase (CDK) 4 protein kinase inhibitor

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PKI-NSC625-010

Availability: within 3 days

143,00 €

Background: NSC 625987 is a selective and potent cyclin-dependent kinase (CDK) 4 inhibitor (IC50 = 0.2 μM at CDK4/cyclin D1). Displays > 500-fold selectivity over CDK2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E). 

Chemical formula: C15H13NO2S
Molecular weight: 271.33 g/mol
Purity: >98%
Solubility: Soluble in DMSO
Appearance: Brown solid
CAS Number: 141992-47-4

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers. 

References

A Kubo et al. The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin. Cancer Res. 1999, 5, 4279-4286.

McInnes et al (2004) Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors. Chem.Biol. 11 525. PMID: 15123247.

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